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Article

Allele-specific silencing by RNAi of R92Q and R173W mutations in cardiac troponin T.

Experimental biology and medicine (Maywood, N.J.) - 1 May 2022

Migliore Loredana, Galvagni Federico, Pierantozzi Enrico, Sorrentino Vincenzo, Rossi Daniela

Abstract excerpt

Autosomal dominant mutations in sarcomere proteins such as the cardiac troponin T (TNNT2) are the main genetic causes of human hypertrophic cardiomyopathy and dilated cardiomyopathy. Allele-specific silencing by RNA interference (ASP-RNAi) holds promise as a therapeutic strategy for downregulating a single mutant allele with minimal suppression of the corresponding wild-type allele. Here, we propose ASP-RNAi as a...

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Identifiers

PMID: 35067102
DOI: 10.1177/15353702211072453
PMCID: PMC9160939

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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