Article
Generation and characterization of human induced pluripotent stem cells (iPSCs) from three patients with age-related macular degeneration carrying rare variants in the CFH gene.
Stem cell research - 1 Apr 2022
Koolen Louet, Gagliardi Giuliana, Ten Brink Sofie C A, de Breuk Anita, Heesterbeek Thomas J, Hoyng Carel B, Albert Silvia, den Hollander Anneke I
Abstract excerpt
Age-related macular degeneration (AMD) is a major cause of vision loss among the elderly in the Western world. AMD is multifactorial eye disease with a strong genetic contribution. Here, we report the generation and characterization of induced pluripotent stem cells (iPSCs) derived from peripheral blood mononuclear cells of three patients with AMD carrying rare variants in the complement factor H (CFH) gene....
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