Article
Generation of an iPSC line (SCTCi014-A) and isogenic control line (SCTCi014-A-1) from an age-related macular degeneration patient carrying the variant c.355G>A in the CFI gene.
Stem cell research - 1 Jul 2022
de Jong Sarah, Koolen Louet, Vázquez-Domínguez Irene, de Breuk Anita, Albert Silvia, Hoyng Carel B, Katti Suresh, den Hollander Anneke I, Garanto Alejandro
Abstract excerpt
Age-related macular degeneration (AMD) is a common eye disease among the elderly in the Western world. AMD is a multifactorial disease, with a strong association with genetic variation in the complement system. One of the AMD-associated variants is the c.355G>A (p.Gly119Arg) variant in complement factor I (CFI), a central regulator of complement activation. Here, we report the generation of an iPSC line and its...
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