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Article

Analysis of Dominant HIV Quasispecies Suggests Independent Viral Evolution Within Spinal Granulomas Coinfected with Mycobacterium tuberculosis and HIV-1 Subtype C.

AIDS research and human retroviruses - 1 Mar 2016

Danaviah Sivapragashini, de Oliveira Tulio, Gordon Michelle, Govender Shunmugam, Chelule Paul, Pillay Sureshnee, Naicker Thajasvarie, Cassol Sharon, Ndung'u Thumbi

Abstract excerpt

Extrapulmonary tuberculosis (TB) is a significant public health challenge in South Africa and worldwide, largely fuelled by the HIV epidemic. In spinal TB, Mycobacteria infect the spinal column without dissemination to the spinal cord. The immune microenvironment, target cell characteristics, and other evolutionary forces within granulomas during HIV/TB coinfection are poorly characterized. We investigated...

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Share to Coinfection
Share to env Gene Products, Human Immunodeficiency Virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Granuloma

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Share to Reverse Transcriptase Polymerase Chain Reaction

Share to RNA, Viral

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Source

Open in PubMed Open full text

Identifiers

PMID: 26564424
DOI: 10.1089/AID.2015.0189
PMCID: PMC5125288

Genes

CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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