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Article

P2X7 receptor-deficient mice are susceptible to bone cancer pain.

Pain - 1 Aug 2011

Hansen Rikke Rie, Nielsen Christian K, Nasser Arafat, Thomsen Stine I M, Eghorn Laura F, Pham Yen, Schulenburg Cecilia, Syberg Susanne, Ding Ming, Stojilkovic Stanko S, Jorgensen Niklas R, Heegaard Anne-Marie

Abstract excerpt

The purinergic P2X7 receptor is implicated in both neuropathic and inflammatory pain, and has been suggested as a possible target in pain treatment. However, the specific role of the P2X7 receptor in bone cancer pain is unknown. We demonstrated that BALB/cJ P2X7 receptor knockout (P2X7R KO) mice were susceptible to bone cancer pain and moreover had an earlier onset of pain-related behaviours compared with...

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Identifiers

PMID: 21565445
DOI: 10.1016/j.pain.2011.03.024
PMCID: PMC6463294

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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