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Article

Risk of congenital heart defects is influenced by genetic variation in folate metabolism.

Cardiology in the young - 1 Feb 2013

Christensen Karen E, Zada Yassamin Feroz, Rohlicek Charles V, Andelfinger Gregor U, Michaud Jacques L, Bigras Jean-Luc, Richter Andrea, Dubé Marie-Pierre, Rozen Rima

Abstract excerpt

Genetic disturbances in folate metabolism may increase risk for congenital heart defects. We examined the association of heart defects with four polymorphisms in folate-related genes (methylenetetrahydrofolate reductase (MTHFR) c.677C.T, MTHFR c.1298A.C, methionine synthase reductase (MTRR) c.66A.G, and reduced folate carrier (SLC19A1) c.80A.G) in a case-control study of children (156 patients, 69 controls) and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Folic Acid

Share to Heart Defects, Congenital

Share to Heart Septal Defects, Ventricular

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Source

Identifiers

PMID: 22475273
DOI: 10.1017/S1047951112000431

Genes

MTHFR
MTRR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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