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Article

Phenotyping Zebrafish Mutant Models to Assess Candidate Genes Associated with Aortic Aneurysm.

Genes - 10 Jan 2022

Prendergast Andrew, Ziganshin Bulat A, Papanikolaou Dimitra, Zafar Mohammad A, Nicoli Stefania, Mukherjee Sandip, Elefteriades John A

Abstract excerpt

(1) Background: Whole Exome Sequencing of patients with thoracic aortic aneurysm often identifies "Variants of Uncertain Significance" (VUS), leading to uncertainty in clinical management. We assess a novel mechanism for potential routine assessment of these genes in TAA patients. Zebrafish are increasingly used as experimental models of disease. Advantages include low cost, rapid maturation, and physical...

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Source

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Identifiers

PMID: 35052463
DOI: 10.3390/genes13010123
PMCID: PMC8775119

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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