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Article

A Preliminary Zebrafish Model of ACTA2 Deficiency Reveals Increased Larval Phenotype Burden and Suggests Reduced Adult Mutant Survival.

Genes - 15 Jul 2026

Zafar Mohammad A, Harling Lisa C, Li Yupeng, Celik Nafiye B, Mukherjee Sandip K, Rizzo John, Prendergast Andrew, Elefteriades John A

Abstract excerpt

BACKGROUND: ACTA2 encodes smooth muscle alpha-actin and is one of the most common genetic causes of inherited non-syndromic thoracic aortic aneurysm and dissection. Although murine models have provided important mechanistic insight, complementary vertebrate systems may enable more rapid in vivo phenotyping and future therapeutic screening. METHODS: Utilizing a CRISPR/Cas9-based approach, we developed zebrafish...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42510848
DOI: 10.3390/genes17070808
PMCID: PMC13409388

Genes

ACTA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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A Preliminary Zebrafish Model of ACTA2 Deficiency Reveals Increased Larval Phenotype Burden and Suggests Reduced Adult Mutant Survival.PMID 42510848Read ↗

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