Article

Functional surrogacy enables Vascular Ehlers-Danlos Syndrome modelling in zebrafish in the absence of a <i>COL3A1</i> ortholog

2026-07-08

Abstract excerpt

<h4>ABSTRACT</h4> Pathogenic variants in COL3A1 cause Vascular Ehlers-Danlos syndrome (vEDS), a rare connective tissue disorder characterised by vascular fragility, increasing the risk of arterial ruptures/dissection. Advances in genomic sequencing have led to an increasing number of COL3A1 variants where the clinical significance is unclear, with these being termed ‘variants of uncertain significance’ (VUS). V...

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Literature Corpus work: 11eb98d5-58e3-560b-9642-4364d48c50d2
DOI: 10.64898/2026.07.03.736265

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