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Article

CRISPR/Cas9 in zebrafish: An attractive model for FBN1 genetic defects in humans.

Molecular genetics & genomic medicine - 1 Oct 2021

Yin Xiaoyun, Hao Jianxiu, Yao Yuanqing

Abstract excerpt

BACKGROUND: Mutations in the fibrillin-1 gene (FBN1) are associated with various heritable connective tissue disorders (HCTD). The most studied HCTD is Marfan syndrome. Ninety percent of Marfan syndrome is caused by mutations in the FBN1 gene. The zebrafish share high genetic similarity to humans, representing an ideal model for genetic research of human diseases. This study aimed to generate and characterize...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34324266
DOI: 10.1002/mgg3.1775
PMCID: PMC8580104

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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