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Metabolic reprogramming regulated by TRAF6 contributes to the leukemia progression

12 Apr 2024

Abstract excerpt

TNF receptor associated factor 6 (TRAF6) is an E3 ubiquitin ligase that has been implicated in myeloid malignancies. Although altered TRAF6 expression is observed in human acute myeloid leukemia (AML), its role in the AML pathogenesis remains elusive. In this study, we showed that the loss of TRAF6 in AML cells significantly impairs leukemic function in vitro and in vivo, indicating its functional importance in...

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PMID: 38609495
DOI: 10.1038/s41375-024-02245-3

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