Article
Identification of a Permissive Secondary Mutation That Restores the Enzymatic Activity of Oseltamivir Resistance Mutation H275Y.
Journal of virology - 23 Mar 2022
Jiang Li, Samant Neha, Liu Ping, Somasundaran Mohan, Jensen Jeffrey D, Marasco Wayne A, Kowalik Timothy F, Schiffer Celia A, Finberg Robert W, Wang Jennifer P, Bolon Daniel N A
Abstract excerpt
Many oseltamivir resistance mutations exhibit fitness defects in the absence of drug pressure that hinders their propagation in hosts. Secondary permissive mutations can rescue fitness defects and facilitate the segregation of resistance mutations in viral populations. Previous studies have identified a panel of permissive or compensatory mutations in neuraminidase (NA) that restore the growth defect of the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.