Article
Oseltamivir-resistant influenza A(H1N1)pdm2009 strains found in Brazil are endowed with permissive mutations, which compensate the loss of fitness imposed by antiviral resistance.
Memorias do Instituto Oswaldo Cruz - 1 Feb 2015
Lopes e Souza Thiago Moreno, Fintelman-Rodrigues Natalia, Resende Paola Cristina, Mesquita Milene, Gregianini Tatiana Schaffer, Bozza Fernando A, Pecego Ana Carla, Fernandes Sandra Bianchini, Cury Ana Luisa Furtado, Riediger Irina Nastassja, Siqueira Marilda M
Abstract excerpt
The 2009 pandemic influenza A virus outbreak led to the systematic use of the neuraminidase (NA) inhibitor oseltamivir (OST). Consequently, OST-resistant strains, carrying the mutation H275Y, emerged in the years after the pandemics, with a prevalence of 1-2%. Currently, OST-resistant strains have been found in community settings, in untreated individuals. To spread in community settings, H275Y mutants must...
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