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Article

Predicting Permissive Mutations That Improve the Fitness of A(H1N1)pdm09 Viruses Bearing the H275Y Neuraminidase Substitution.

Journal of virology - 10 Aug 2022

Farrukee Rubaiyea, Gunalan Vithiagaran, Maurer-Stroh Sebastian, Reading Patrick C, Hurt Aeron C

Abstract excerpt

Oseltamivir-resistant influenza viruses arise due to amino acid mutations in key residues of the viral neuraminidase (NA). These changes often come at a fitness cost; however, it is known that permissive mutations in the viral NA can overcome this cost. This result was observed in former seasonal A(H1N1) viruses in 2007 which expressed the H275Y substitution (N1 numbering) with no apparent fitness cost and lead...

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Identifiers

PMID: 35867563
DOI: 10.1128/jvi.00918-22
PMCID: PMC9364793

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