Preneoplastic somatic mutations including MYD88L265P in lymphoplasmacytic lymphoma.

doi:10.1126/sciadv.abl4644

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Article

Preneoplastic somatic mutations including MYD88L265P in lymphoplasmacytic lymphoma.

Science advances - 21 Jan 2022

Rodriguez Sara, Celay Jon, Goicoechea Ibai, Jimenez Cristina, Botta Cirino, Garcia-Barchino Maria-José, Garces Juan-Jose, Larrayoz Marta, Santos Susana, Alignani Diego, Vilas-Zornoza Amaia, Perez Cristina, Garate Sonia, Sarvide Sarai, Lopez Aitziber, Reinhardt Hans-Christian, Carrasco Yolanda R, Sanchez-Garcia Isidro, Larrayoz Maria-Jose, Calasanz Maria-Jose, Panizo Carlos, Prosper Felipe, Lamo-Espinosa Jose-Maria, Motta Marina, Tucci Alessandra, Sacco Antonio, Gentile Massimo, Duarte Sara, Vitoria Helena, Geraldes Catarina, Paiva Artur, Puig Noemi, Garcia-Sanz Ramon, Roccaro Aldo M, Fuerte Gema, San Miguel Jesus F, Martinez-Climent Jose-Angel, Paiva Bruno

Abstract excerpt

Normal cell counterparts of solid and myeloid tumors accumulate mutations years before disease onset; whether this occurs in B lymphocytes before lymphoma remains uncertain. We sequenced multiple stages of the B lineage in elderly individuals and patients with lymphoplasmacytic lymphoma, a singular disease for studying lymphomagenesis because of the high prevalence of mutated MYD88. We observed similar...

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PMID: 35044826
DOI: 10.1126/sciadv.abl4644
PMCID: PMC8769557

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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