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Article

Identification of a diarylpentanoid-producing polyketide synthase revealing an unusual biosynthetic pathway of 2-(2-phenylethyl)chromones in agarwood.

Nature communications - 17 Jan 2022

Wang Xiao-Hui, Gao Bo-Wen, Nakashima Yu, Mori Takahiro, Zhang Zhong-Xiu, Kodama Takeshi, Lee Yuan-E, Zhang Ze-Kun, Wong Chin-Piow, Liu Qian-Qian, Qi Bo-Wen, Wang Juan, Li Jun, Liu Xiao, Abe Ikuro, Morita Hiroyuki, Tu Peng-Fei, Shi She-Po

Abstract excerpt

2-(2-Phenylethyl)chromones (PECs) are the principal constituents contributing to the distinctive fragrance of agarwood. How PECs are biosynthesized is currently unknown. In this work, we describe a diarylpentanoid-producing polyketide synthase (PECPS) identified from Aquilaria sinensis. Through biotransformation experiments using fluorine-labeled substrate, transient expression of PECPS in Nicotiana benthamiana,...

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Identifiers

PMID: 35039506
DOI: 10.1038/s41467-022-27971-z
PMCID: PMC8764113

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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