Article
Mutation screening of the DNAJC7 gene in Japanese patients with sporadic amyotrophic lateral sclerosis.
Neurobiology of aging - 1 May 2022
Tohnai Genki, Nakamura Ryoichi, Atsuta Naoki, Nakatochi Masahiro, Hayashi Naoki, Ito Daisuke, Watanabe Hazuki, Watanabe Hirohisa, Katsuno Masahisa, Izumi Yuishin, Taniguchi Akira, Kanai Kazuaki, Morita Mitsuya, Kano Osamu, Kuwabara Satoshi, Oda Masaya, Abe Koji, Aoki Masashi, Aiba Ikuko, Okamoto Koichi, Mizoguchi Kouichi, Ishihara Tomohiko, Kawata Akihiro, Yokota Takanori, Hasegawa Kazuko, Nagano Isao, Yabe Ichiro, Tanaka Fumiaki, Kuru Satoshi, Hattori Nobutaka, Nakashima Kenji, Kaji Ryuji, Sobue Gen
Abstract excerpt
DNAJC7 has recently been identified as an amyotrophic lateral sclerosis (ALS) gene via large-scale exome analysis, and its involvement in ALS is still unclear in various populations. This study aimed to determine the frequencies and characteristics of the DNAJC7 variants in a Japanese ALS cohort. A total of 807 unrelated Japanese patients with sporadic ALS were screened via exome analysis. In total, we detected...
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