Article
Mutations of DNAJC7 are rare in Chinese amyotrophic lateral sclerosis patients.
Amyotrophic lateral sclerosis & frontotemporal degeneration - 1 May 2021
Sun Xiaohan, Zhao Ximeng, Liu Qing, Zhang Kang, Liu Shuangwu, Wang Zhili, Yang Xunzhe, Shang Liang, Cui Liying, Zhang Xue
Abstract excerpt
BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive injury of both upper and lower motor neurons. Recently, protein-truncating and missense mutations of DNAJC7 have been reported in European ALS cohorts. However, the contribution of DNAJC7 mutations in Asian patients with ALS remains unclear. Methods: DNAJC7 mutation screening was performed in a large...
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