Next-generation sequencing of 28 ALS-related genes in a Japanese ALS cohort.

doi:10.1016/j.neurobiolaging.2015.11.030

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Article

Next-generation sequencing of 28 ALS-related genes in a Japanese ALS cohort.

Neurobiology of aging - 1 Mar 2016

Nakamura Ryoichi, Sone Jun, Atsuta Naoki, Tohnai Genki, Watanabe Hazuki, Yokoi Daichi, Nakatochi Masahiro, Watanabe Hirohisa, Ito Mizuki, Senda Jo, Katsuno Masahisa, Tanaka Fumiaki, Li Yuanzhe, Izumi Yuishin, Morita Mitsuya, Taniguchi Akira, Kano Osamu, Oda Masaya, Kuwabara Satoshi, Abe Koji, Aiba Ikuko, Okamoto Koichi, Mizoguchi Kouichi, Hasegawa Kazuko, Aoki Masashi, Hattori Nobutaka, Tsuji Shoji, Nakashima Kenji, Kaji Ryuji, Sobue Gen

Abstract excerpt

We investigated the frequency and contribution of variants of the 28 known amyotrophic lateral sclerosis (ALS)-related genes in Japanese ALS patients. We designed a multiplex, polymerase chain reaction-based primer panel to amplify the coding regions of the 28 ALS-related genes and sequenced DNA samples from 257 Japanese ALS patients using an Ion Torrent PGM sequencer. We also performed exome sequencing and...

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PMID: 26742954
DOI: 10.1016/j.neurobiolaging.2015.11.030

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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