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Exome sequencing identifies a recurrent variant in SERPINA3 associating with hereditary susceptibility to breast cancer

3 Dec 2020

Abstract excerpt

BACKGROUND: Breast cancer is strongly influenced by hereditary risk factors. Yet, the known susceptibility genes and genomic loci explain only about half of the familial component of the disease. To identify novel breast cancer predisposing gene defects, here we have performed massive parallel sequencing for Northern Finnish breast cancer cases. METHODS: Ninety-eight breast cancer cases with indication of...

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PMID: 33279852
DOI: 10.1016/j.ejca.2020.10.033

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