Article
Ocular Phenotyping of Knockout Mice Identifies Genes Associated With Late Adult Retinal Phenotypes.
Investigative ophthalmology & visual science - 2 Jun 2025
Hang Abraham, Shao Andy, Shea Michael, Roux Michel J, Imai-Leonard Denise M, Adams David J, Amano Takanori, Amarie Oana V, Berberovic Zorana, Bour Raphaël, Bower Lynette, Leonard Brian C, Brown Steve D, Cho Soo Young, Clementson-Mobbs Sharon, D'Souza Abigail J, Dickinson Mary, Eskandarian Mohammad, Flenniken Ann M, Fuchs Helmut, Gailus-Durner Valerie, Heaney Jason, Hérault Yann, Hrabe de Angelis Martin, Hsu Chih-Wei, Jin Shundan, Joynson Russell, Kang Yeon Kyung, Kim Haerim, Masuya Hiroshi, Nam Ki-Hoan, Noh Hyuna, Nutter Lauryl M J, Palkova Marcela, Prochazka Jan, Raishbrook Miles Joseph, Riet Fabrice, Salazar Jason, Seavitt John Richard, Sedlacek Radislav, Selloum Mohammed, Seo Kyoung Yul, Seong Je Kyung, Shin Hae-Sol, Shiroishi Toshihiko, Sorg Tania, Stewart Michelle, Tamura Masaru, Tolentino Heather, Udensi Uchechukwu, Wells Sara, Wurst Wolfgang, Yoshiki Atsushi, Meziane Hamid, Yiu Glenn, Sieving Paul A, Lanoue Louise, Lloyd K C Kent, McKerlie Colin, Moshiri Ala
Abstract excerpt
Purpose: Analyze phenotypic data from knockout mice with late-adult retinal pathologic phenotypes to identify genes associated with development of adult-onset retinal diseases. Methods: The International Mouse Phenotyping Consortium (IMPC) database was queried for genes associated with abnormal retinal phenotypes in the late-adult knockout mouse pipeline (49-80 weeks postnatal age). We identified human orthologs...
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