Article
Selective influence of rat genotype on age-related regional changes in forebrain muscarinic binding.
Neurobiology of aging - 1 Jan 2000
Gilad G M, Rabey J M, Shenkman L, Gilad V H
Abstract excerpt
Muscarinic binding was analyzed in the hippocampus and frontal cerebral cortex of 3 (young) and 24-month-old (aged) inbred Wistar-Kyoto (WKY), Brown-Norway (BN) and Lewis rats, by the specific binding of the antagonist quinuclidinylbenzilate (QNB). While no age-related changes were detected in the hippocampus of all strains, complex changes were found in the cortex. Maximal binding capacity (Bmax) of [3H]QNB was...
Topics
- Aging
- Animals
- Frontal Lobe
- Genotype
- Hippocampus
- Male
- Quinuclidinyl Benzilate
- Rats
- Rats, Inbred BN
- Rats, Inbred Lew
- Rats, Inbred WKY
- Receptors, Muscarinic