Article
Interplay of Dinner Timing and MTNR1B Type 2 Diabetes Risk Variant on Glucose Tolerance and Insulin Secretion: A Randomized Crossover Trial.
Diabetes care - 1 Mar 2022
Garaulet Marta, Lopez-Minguez Jesus, Dashti Hassan S, Vetter Céline, Hernández-Martínez Antonio Miguel, Pérez-Ayala Millán, Baraza Juan Carlos, Wang Wei, Florez Jose C, Scheer Frank A J L, Saxena Richa
Abstract excerpt
OBJECTIVE: We tested whether the concurrence of food intake and elevated concentrations of endogenous melatonin, as occurs with late eating, results in impaired glucose control, in particular in carriers of the type 2 diabetes-associated G allele in the melatonin receptor-1B gene (MTNR1B). RESEARCH DESIGN AND METHODS: In a Spanish natural late-eating population, a randomized, crossover study was performed. Each...
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