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Article

Preparation and In Vitro Evaluation of RITUXfab-Decorated Lipoplexes to Improve Delivery of siRNA Targeting C1858T PTPN22 Variant in B Lymphocytes.

International journal of molecular sciences - 30 Dec 2021

Arena Andrea, Belcastro Eugenia, Accardo Antonella, Sandomenico Annamaria, Pagliarosi Olivia, Rosa Elisabetta, Petrini Stefania, Conti Libenzio Adrian, Giorda Ezio, Corsetti Tiziana, Schiaffini Riccardo, Morelli Giancarlo, Fierabracci Alessandra

Abstract excerpt

Autoimmune endocrine disorders, such as type 1 diabetes (T1D) and thyroiditis, at present are treated with only hormone replacement therapy. This emphasizes the need to identify personalized effective immunotherapeutic strategies targeting T and B lymphocytes. Among the genetic variants associated with several autoimmune disorders, the C1858T polymorphism of the protein tyrosine phosphatase non-receptor type 22...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35008834
DOI: 10.3390/ijms23010408
PMCID: PMC8745767

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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