Combination of Genomic and Transcriptomic Approaches Highlights Vascular and Circadian Clock Components in Multiple Sclerosis.

doi:10.3390/ijms23010310

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Article

Combination of Genomic and Transcriptomic Approaches Highlights Vascular and Circadian Clock Components in Multiple Sclerosis.

International journal of molecular sciences - 28 Dec 2021

Scapoli Chiara, Ziliotto Nicole, Lunghi Barbara, Menegatti Erica, Salvi Fabrizio, Zamboni Paolo, Baroni Marcello, Mascoli Francesco, Bernardi Francesco, Marchetti Giovanna

Abstract excerpt

Aiming at exploring vascular components in multiple sclerosis (MS) with brain outflow disturbance, we combined transcriptome analysis in MS internal jugular vein (IJV) wall with WES in MS families with vertical transmission of disease. Main results were the differential expression in IJV wall of 16 MS-GWAS genes and of seven genes (GRIN2A, GRIN2B, IL20RB, IL26, PER3, PITX2, and PPARGC1A) not previously indicated...

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PMID: 35008743
DOI: 10.3390/ijms23010310
PMCID: PMC8745220

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