Article
Custom CGH array profiling of copy number variations (CNVs) on chromosome 6p21.32 (HLA locus) in patients with venous malformations associated with multiple sclerosis.
BMC medical genetics - 28 Apr 2010
Ferlini Alessandra, Bovolenta Matteo, Neri Marcella, Gualandi Francesca, Balboni Alessandra, Yuryev Anton, Salvi Fabrizio, Gemmati Donato, Liboni Alberto, Zamboni Paolo
Abstract excerpt
BACKGROUND: Multiple sclerosis (MS) is a complex disorder thought to result from an interaction between environmental and genetic predisposing factors which have not yet been characterised, although it is known to be associated with the HLA region on 6p21.32. Recently, a picture of chronic cerebrospinal venous insufficiency (CCSVI), consequent to stenosing venous malformation of the main extra-cranial outflow...
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