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Article

Hot Spot Mutagenesis Improves the Functional Expression of Unique Mammalian Odorant Receptors.

International journal of molecular sciences - 28 Dec 2021

Fukutani Yosuke, Nakamura Yuko, Muto Nonoko, Miyanaga Shunta, Kanemaki Reina, Ikegami Kentaro, Noguchi Keiichi, Ohsawa Ikuroh, Matsunami Hiroaki, Yohda Masafumi

Abstract excerpt

Vertebrate animals detect odors through olfactory receptors (ORs), members of the G protein-coupled receptor (GPCR) family. Due to the difficulty in the heterologous expression of ORs, studies of their odor molecule recognition mechanisms have progressed poorly. Functional expression of most ORs in heterologous cells requires the co-expression of their chaperone proteins, receptor transporting proteins (RTPs)....

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PMID: 35008703
DOI: 10.3390/ijms23010277
PMCID: PMC8745346

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