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Article

Genomic HEXploring allows landscaping of novel potential splicing regulatory elements.

Nucleic acids research - 1 Jan 2014

Erkelenz Steffen, Theiss Stephan, Otte Marianne, Widera Marek, Peter Jan Otto, Schaal Heiner

Abstract excerpt

Effective splice site selection is critically controlled by flanking splicing regulatory elements (SREs) that can enhance or repress splice site use. Although several computational algorithms currently identify a multitude of potential SRE motifs, their predictive power with respect to mutation effects is limited. Following a RESCUE-type approach, we defined a hexamer-based 'HEXplorer score' as average Z-score of...

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PMID: 25147205
DOI: 10.1093/nar/gku736
PMCID: PMC4176321

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