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Article

Host tp53 mutation induces gut dysbiosis eliciting inflammation through disturbed sialic acid metabolism.

Microbiome - 6 Jan 2022

Lee Jae-Geun, Lee Soohyun, Jeon Juhee, Kong Hyun Gi, Cho Hyun-Ju, Kim Jong-Hwan, Kim Seon-Young, Oh Myung Jin, Lee Daum, Seo Nari, Park Ki Hun, Yu Kweon, An Hyun Joo, Ryu Choong-Min, Lee Jeong-Soo

Abstract excerpt

BACKGROUND: Host tp53 mutations are frequently found during the early stages of colitis-associated colorectal cancer (CAC), but whether such mutations induce gut microbiota dysbiosis and chronic intestinal inflammation that contributes to the development of CAC, remains unknown. RESULTS: We found that zebrafish tp53 mutant larvae exhibited elevated intestinal inflammation, by monitoring the NFκB activity in the...

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Identifiers

PMID: 34991725
DOI: 10.1186/s40168-021-01191-x
PMCID: PMC8733924

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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