Article
The clinical significance of adenomatous polyposis coli (APC) and catenin Beta 1 (CTNNB1) genetic aberrations in patients with melanoma.
BMC cancer - 5 Jan 2022
Karachaliou Georgia Sofia, Alkallas Rached, Carroll Sarah B, Caressi Chongshan, Zakria Danny, Patel Nirali M, Trembath Dimitri G, Ezzell Jennifer A, Pegna Guillaume J, Googe Paul B, Galeotti Jonathan P, Ayvali Fatih, Collichio Frances A, Lee Carrie B, Ollila David W, Gulley Margaret L, Johnson Douglas B, Kim Kevin B, Watson Ian R, Moschos Stergios J
Abstract excerpt
BACKGROUND: Melanoma-intrinsic activated β-catenin pathway, the product of the catenin beta 1 (CTNNB1) gene, has been associated with low/absent tumor-infiltrating lymphocytes, accelerated tumor growth, metastases development, and resistance to anti-PD-L1/anti-CTLA-4 agents in mouse melanoma models. Little is known about the association between the adenomatous polyposis coli (APC) and CTNNB1 gene mutations in...
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