Deletion of murine Rhoh leads to de-repression of Bcl-6 via decreased KAISO levels and accelerates a malignancy phenotype in a murine model of lymphoma.

doi:10.1080/21541248.2021.2019503

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Deletion of murine Rhoh leads to de-repression of Bcl-6 via decreased KAISO levels and accelerates a malignancy phenotype in a murine model of lymphoma.

Small GTPases - 1 Jan 2022

Horiguchi Hiroto, Xu Haiming, Duvert Beatrice, Ciuculescu Felicia, Yao Qiuming, Sinha Amit, McGuinness Meaghan, Harris Chad, Brendel Christian, Troeger Anja, Chiarle Roberto, Williams David A

Abstract excerpt

RHOH/TFF, a member of the RAS GTPase super family, has important functions in lymphopoiesis and proximal T cell receptor signalling and has been implicated in a variety of leukaemias and lymphomas. RHOH was initially identified as a translocation partner with BCL-6 in non-Hodgkin lymphoma (NHL), and aberrant somatic hypermutation (SHM) in the 5' untranslated region of the RHOH gene has also been detected in...

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Deletion of murine Rhoh leads to de-repression of Bcl-6 via decreased KAISO levels and accelerates a malignancy phenotype in a murine model of lymphoma.

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