Article
Genetic Variants in Epigenetic Pathways and Risks of Multiple Cancers in the GAME-ON Consortium.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jun 2017
Toth Reka, Scherer Dominique, Kelemen Linda E, Risch Angela, Hazra Aditi, Balavarca Yesilda, Issa Jean-Pierre J, Moreno Victor, Eeles Rosalind A, Ogino Shuji, Wu Xifeng, Ye Yuanqing, Hung Rayjean J, Goode Ellen L, Ulrich Cornelia M
Abstract excerpt
Background: Epigenetic disturbances are crucial in cancer initiation, potentially with pleiotropic effects, and may be influenced by the genetic background.Methods: In a subsets (ASSET) meta-analytic approach, we investigated associations of genetic variants related to epigenetic mechanisms with risks of breast, lung, colorectal, ovarian and prostate carcinomas using 51,724 cases and 52,001 controls. False...
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