Article
A draft fur seal genome provides insights into factors affecting SNP validation and how to mitigate them.
Molecular ecology resources - 1 Jul 2016
Humble E, Martinez-Barrio A, Forcada J, Trathan P N, Thorne M A S, Hoffmann M, Wolf J B W, Hoffman J I
Abstract excerpt
Custom genotyping arrays provide a flexible and accurate means of genotyping single nucleotide polymorphisms (SNPs) in a large number of individuals of essentially any organism. However, validation rates, defined as the proportion of putative SNPs that are verified to be polymorphic in a population, are often very low. A number of potential causes of assay failure have been identified, but none have been explored...
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