Mendelian randomization analyses support causal relationships between blood metabolites and the gut microbiome.

doi:10.1038/s41588-021-00968-y

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Article

Mendelian randomization analyses support causal relationships between blood metabolites and the gut microbiome.

Nature genetics - 1 Jan 2022

Liu Xiaomin, Tong Xin, Zou Yuanqiang, Lin Xiaoqian, Zhao Hui, Tian Liu, Jie Zhuye, Wang Qi, Zhang Zhe, Lu Haorong, Xiao Liang, Qiu Xuemei, Zi Jin, Wang Rong, Xu Xun, Yang Huanming, Wang Jian, Zong Yang, Liu Weibin, Hou Yong, Zhu Shida, Jia Huijue, Zhang Tao

Abstract excerpt

The gut microbiome has been implicated in a variety of physiological states, but controversy over causality remains unresolved. Here, we performed bidirectional Mendelian randomization analyses on 3,432 Chinese individuals with whole-genome, whole-metagenome, anthropometric and blood metabolic trait data. We identified 58 causal relationships between the gut microbiome and blood metabolites, and replicated 43 of...

Read the complete abstract on PubMed