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Article

Amyotrophic Lateral Sclerosis (ALS) Genetics and Microbiota: A Comprehensive Review.

International journal of molecular sciences - 19 Feb 2026

Kurdi Mostafa Ahmed, Alotaibi Hidayah, Alkhuraymi Asayel Tawfiq, Aldahery Layyan Nassar, Alhawaj Ali Fouad, Aldali Hamzah Jehad

Abstract excerpt

Amyotrophic Lateral Sclerosis (ALS) is a severe, progressive neurodegenerative disorder characterized by the loss of upper and lower motor neurons, affecting 0.5 to 2.6 per 100,000 people, with a median survival of 2 to 5 years. It is increasingly seen as a multisystem disorder, sharing essential clinicopathological features with Frontotemporal Dementia (FTD). This convergence arises from overlapping molecular...

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Identifiers

PMID: 41752118
DOI: 10.3390/ijms27041978
PMCID: PMC12941290

Genes

SOD1
FUS
TARDBP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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