Article
Crystal Structures of Bat and Human Coronavirus ORF8 Protein Ig-Like Domain Provide Insights Into the Diversity of Immune Responses.
Frontiers in immunology - 1 Jan 2021
Chen Xiaoxue, Zhou Zhechong, Huang Chunliu, Zhou Ziliang, Kang Sisi, Huang Zhaoxia, Jiang Guanmin, Hong Zhongsi, Chen Qiuyue, Yang Mei, He Suhua, Liu Siqi, Chen Jie, Li Kenan, Li Xin, Liao Jing, Chen Jun, Chen Shoudeng
Abstract excerpt
ORF8 is a viral immunoglobulin-like (Ig-like) domain protein encoded by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA genome. It tends to evolve rapidly and interfere with immune responses. However, the structural characteristics of various coronavirus ORF8 proteins and their subsequent effects on biological functions remain unclear. Herein, we determined the crystal structures of...
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