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Article

A novel two-factor monosynaptic TRIO tracing method for assessment of circuit integration of hESC-derived dopamine transplants.

Stem cell reports - 11 Jan 2022

Aldrin-Kirk Patrick, Åkerblom Malin, Cardoso Tiago, Nolbrant Sara, Adler Andrew F, Liu Xiaohe, Heuer Andreas, Davidsson Marcus, Parmar Malin, Björklund Tomas

Abstract excerpt

Transplantation in Parkinson's disease using human embryonic stem cell (hESC)-derived dopaminergic (DA) neurons is a promising future treatment option. However, many of the mechanisms that govern their differentiation, maturation, and integration into the host circuitry remain elusive. Here, we engrafted hESCs differentiated toward a ventral midbrain DA phenotype into the midbrain of a preclinical rodent model of...

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Identifiers

PMID: 34971563
DOI: 10.1016/j.stemcr.2021.11.014
PMCID: PMC8758947

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