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Article

Oncogenic FGFR1 mutation and amplification in common cellular origin in a composite tumor with neuroblastoma and pheochromocytoma.

Cancer science - 1 Apr 2022

Tasaka Keiji, Ueno Hiroo, Yamasaki Kai, Okuno Takahiro, Isobe Tomoya, Kimura Shunsuke, Umeda Katsutsugu, Hara Junichi, Ogawa Seishi, Takita Junko

Abstract excerpt

Neuroblastoma (NB) and pheochromocytoma (PCC) are derived from neural crest cells (NCCs); however, composite tumors with NB and PCC are rare, and their underlying molecular mechanisms remain unknown. To address this issue, we performed exome and transcriptome sequencing with formalin-fixed paraffin-embedded (FFPE) samples from the NB, PCC, and mixed lesions in a patient with a composite tumor. Whole-exome...

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Identifiers

PMID: 34971484
DOI: 10.1111/cas.15260
PMCID: PMC8990717

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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