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Article

YAP/miR-524-5p axis negatively regulates TXNIP expression to promote chondrosarcoma cell growth.

Biochemical and biophysical research communications - 29 Jan 2022

Liu Ri-Xu, Tang Wang, Zheng Bo-Yuan, Yang Yong, Li Zhen-Yan, Gui Tao, Zhang Huan-Tian, Liu Ning, Zha Zhen-Gang, Li Jing-Xiang

Abstract excerpt

Chondrosarcoma (CHS) is the second most common bone malignant tumor and currently has limited treatment options. We have recently demonstrated that thioredoxin interacting protein (TXNIP) plays a crucial role in the oncogenesis of bone sarcoma, yet its implication in CHS is underdetermined. In the present study, we first found that knockdown of TXNIP promotes the proliferation of CHS cell largely through...

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PMID: 34968780
DOI: 10.1016/j.bbrc.2021.12.052

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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