Article

MEK5-ERK5 pathway mediates mitophagy by regulating Nur77 to promote tumorigenesis of osteosarcoma cells

2024-07-23

Abstract excerpt

<title>Abstract</title> <p>Objective To investigate the influence of MEK5/ERK5 pathway on mitophagy in osteosarcoma (OS), as well as the involved molecular mechanisms. Methods The overlapped genes of mitophagy-related genes from MSigDB database and DEGs between metastatic and primary OS groups from GSE32981 were identified. GSVA of mitophagy-related pathways between the metastatic and primary groups were analyz...

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Literature Corpus work: 3c70bda6-9ad8-5b39-8670-0aae3a0659d9
DOI: 10.21203/rs.3.rs-4609984/v1

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