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The α2-adrenergic receptor pathway modulating depression influences the risk of arterial thrombosis associated with BDNFVal66Met polymorphism.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Feb 2022

Sandrini Leonardo, Amadio Patrizia, Ieraci Alessandro, Malara Alessandro, Werba José P, Soprano Paolo M, Balduini Alessandra, Zarà Marta, Bonomi Alice, Veglia Fabrizio, Colombo Gualtiero I, Popoli Maurizio, Lee Francis S, Tremoli Elena, Barbieri Silvia S

Abstract excerpt

Depression is associated with thrombotic risk and arterial events, its proper management is strongly recommended in coronary artery disease (CAD) patients. We have previously shown that the Brain-Derived Neurotrophic Factor (BDNF)Val66Met polymorphism, related to depression, is associated with arterial thrombosis in mice, and with an increased risk of acute myocardial infarction in humans. Herein, expanding the...

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Identifiers

PMID: 34965503
DOI: 10.1016/j.biopha.2021.112557

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