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Article

Brain‑derived neurotrophic factor gene polymorphisms are associated with coronary artery disease‑related depression and antidepressant response.

Molecular medicine reports - 1 Dec 2014

Liu Yong-Qiang, Su Guo-Bao, Duan Chang-Hong, Wang Jun-Hua, Liu Hai-Mei, Feng Nan, Wang Qing-Xi, Liu Xu-En, Zhang Jie

Abstract excerpt

Depression is a well‑established risk factor for cardiac morbidity and mortality in patients with coronary artery disease (CAD). Previous studies have demonstrated that the level of brain‑derived neurotrophic factor (BDNF) is decreased in depressed patients and this depletion may be reversed by antidepressants. Several recent studies have suggested that BDNF is involved in the pathogenesis of CAD. The aim of the...

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Source

Identifiers

PMID: 25324022
DOI: 10.3892/mmr.2014.2638

Genes

CAD
BDNF

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