Article
Identification of Genetic Risk Factors for Familial Urinary Bladder Cancer: An Exome Sequencing Study.
JCO precision oncology - 1 Jan 2021
Pemov Alexander, Wegman-Ostrosky Talia, Kim Jung, Koutros Stella, Douthitt Brenna, Jones Kristine, Zhu Bin, Baris Dalsu, Schwenn Molly, Johnson Alison, Karagas Margaret R, Carter Brian D, McCullough Marjorie L, Landi Maria Teresa, Freedman Neal D, Albanes Demetrius, Silverman Debra T, Rothman Nathaniel, Caporaso Neil E, Greene Mark H, Fraumeni Joseph F, Stewart Douglas R
Abstract excerpt
PURPOSE: Previous studies have shown an approximately two-fold elevation in the relative risk of urinary bladder cancer (UBC) among people with a family history that could not be entirely explained by shared environmental exposures, thus suggesting a genetic component in its predisposition. Multiple genome-wide association studies and recent gene panel sequencing studies identified several genetic loci that are...
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