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Article

ZRC3308 Monoclonal Antibody Cocktail Shows Protective Efficacy in Syrian Hamsters against SARS-CoV-2 Infection.

Viruses - 3 Dec 2021

Yadav Pragya D, Mendiratta Sanjeev Kumar, Mohandas Sreelekshmy, Singh Arun K, Abraham Priya, Shete Anita, Bandyopadhyay Sanjay, Kumar Sanjay, Parikh Aashini, Kalita Pankaj, Sharma Vibhuti, Pandya Hardik, Patel Chirag G, Patel Mihir, Soni Swagat, Giri Suresh, Jain Mukul

Abstract excerpt

We have developed a monoclonal antibody (mAb) cocktail (ZRC-3308) comprising of ZRC3308-A7 and ZRC3308-B10 in the ratio 1:1 for COVID-19 treatment. The mAbs were designed to have reduced immune effector functions and increased circulation half-life. mAbs showed good binding affinities to non-competing epitopes on RBD of SARS-CoV-2 spike protein and were found neutralizing SARS-CoV-2 variants B.1, B.1.1.7,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34960695
DOI: 10.3390/v13122424
PMCID: PMC8706527

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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