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Blood Levels of the SMOC1 Hepatokine Are Not Causally Linked with Type 2 Diabetes: A Bidirectional Mendelian Randomization Study.

Nutrients - 24 Nov 2021

Ghodsian Nooshin, Gagnon Eloi, Bourgault Jérôme, Gobeil Émilie, Manikpurage Hasanga D, Perrot Nicolas, Girard Arnaud, Mitchell Patricia L, Arsenault Benoit J

Abstract excerpt

Hepatokines are liver-derived proteins that may influence metabolic pathways such as insulin sensitivity. Recently, Sparc-related modular calcium-binding protein 1 (SMOC1) was identified as glucose-responsive hepatokine that is dysregulated in the setting of non-alcoholic fatty liver disease (NAFLD). While SMOC1 may influence glucose-insulin homeostasis in rodents, it is unknown if SMOC1 is influenced by NAFLD in...

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PMID: 34959760
DOI: 10.3390/nu13124208
PMCID: PMC8706295

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