Article
Non-Alcoholic Fatty Liver Disease and Vitamin D in the UK Biobank: A Two-Sample Bidirectional Mendelian Randomisation Study.
Nutrients - 16 Mar 2023
Zhang Zixuan, Burrows Kimberley, Fuller Harriett, Speliotes Elizabeth K, Abeysekera Kushala W M, Thorne James L, Lewis Sarah J, Zulyniak Michael A, Moore J Bernadette
Abstract excerpt
Evidence for a role for vitamin D in non-alcoholic fatty liver disease (NAFLD) pathogenesis is conflicting. As Mendelian randomisation (MR) avoids many limitations of conventional observational studies, this two-sample bidirectional MR analysis was conducted to determine the following: (i) whether genetically predicted 25-hydroxyvitamin D [25(OH)D] levels are a risk factor for NAFLD, and (ii) whether genetic risk...
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