Article
Aberrant interaction between mutated ADAMTSL2 and LTBP4 is associated with adolescent idiopathic scoliosis.
Gene - 10 Mar 2022
Liu Bowen, Zhao Sen, Liu Lian, Du Huakang, Zhao Hengqiang, Wang Shengru, Niu Yuchen, Li Xiaoxin, Qiu Guixing, Wu Zhihong, Zhang Terry Jianguo, Wu Nan
Abstract excerpt
Adolescent idiopathic scoliosis (AIS) is a complex spinal deformity with a prevalence of 1%-3%. Genetic factors have been associated with the etiology of AIS. However, previous studies mainly focused on common single nucleotide polymorphisms which confer modest disease risk. Recently, rare variants in FBN1 and other extracellular matrix genes have been implicated in AIS, suggesting a potential overlapping disease...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.