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Article

Association of FBN1 polymorphism with susceptibility of adolescent idiopathic scoliosis: a case-control study.

BMC musculoskeletal disorders - 7 May 2022

de Azevedo Gustavo Borges Laurindo, Perini Jamila Alessandra, Araújo Junior Antônio Eulálio Pedrosa, Moliterno Luis Antonio Medeiros, Andrande Rodrigo Mantelatto, Guimarães João Antonio Matheus, Defino Helton Luiz Aparecido

Abstract excerpt

BACKGROUND: Fibrillin-1 (FBN1) is an extracellular matrix glycoprotein essential to the structural component of microfibrils and FBN1 gene polymorphisms can be associated with adolescent idiopathic scoliosis (AIS) susceptibility. This study aimed to evaluate the potential role of the FBN1 rs12916536 polymorphism in AIS development or severity and the variation in Cobb angle in relation to patient's...

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Identifiers

PMID: 35526034
DOI: 10.1186/s12891-022-05370-1
PMCID: PMC9077855

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