Article
Mutation of Gly-11 on the dimer interface results in the complete crystallographic dimer dissociation of severe acute respiratory syndrome coronavirus 3C-like protease: crystal structure with molecular dynamics simulations.
The Journal of biological chemistry - 4 Jan 2008
Chen Shuai, Hu Tiancen, Zhang Jian, Chen Jing, Chen Kaixian, Ding Jianping, Jiang Hualiang, Shen Xu
Abstract excerpt
SARS-CoV 3C-like protease (3CL(pro)) is an attractive target for anti-severe acute respiratory syndrome (SARS) drug discovery, and its dimerization has been extensively proved to be indispensable for enzymatic activity. However, the reason why the dissociated monomer is inactive still remains unclear due to the absence of the monomer structure. In this study, we showed that mutation of the dimer-interface residue...
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