Article
CD44, IL-33, and ST2 Gene Polymorphisms on Hepatocellular Carcinoma Susceptibility in the Chinese Population.
BioMed research international - 1 Jan 2020
Pan Xiaolan, Li Meiqin, Huang Lei, Mo Dan, Liang Yihua, Huang Zhaodong, Zhu Bo, Fang Min
Abstract excerpt
The interleukin- (IL-) 33/ST2 axis plays a pivotal role in tumorigenesis through influencing cancer stemness and other mechanisms. CD44 is one of the critical markers of hepatocellular carcinoma (HCC) among the cancer stem cells (CSCs). There is still a lack of CD44 gene single-nucleotide polymorphisms (SNPs) combined with IL-33/ST2 pathway single-nucleotide polymorphisms in HCC susceptibility analysis...
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